2650082-35-0
2650082-35-0
Chemical Structure
PAT-347 sodium
- CAS No.: 2650082-35-0
- Formula:C28H20ClF2N2NaO3S
- Molecular Weight:560.97
IUPAC Name: 3-((6-chloro-7-fluoro-2-methyl-1-(2-oxo-2-(spiro[cyclopropane-1,3'-indolin]-1'-yl)ethyl)-1H-indol-3-yl)thio)-2-fluorobenzoic acid, sodium salt
InChIKey: SSBGAZDYHLKALW-UHFFFAOYSA-M
SMILES: O=C(C1=C(F)C(SC2=C(C)N(CC(N3C4=C(C5(CC5)C3)C=CC=C4)=O)C6=C2C=CC(Cl)=C6F)=CC=C1)O[Na]
Biological Activity: PAT-347 sodium is an Autotaxin (ATX) inhibitor. ATX is a secretory enzyme that hydrolyzes lysophosphatidylcholine (LPC) and regulates lysophosphatidic acid (LPA) production in the blood[1][2].
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PAT-347 sodium | PAT-347 sodium is an Autotaxin (ATX) inhibitor. ATX is a secretory enzyme that hydrolyzes lysophosphatidylcholine (LPC) and regulates lysophosphatidic acid (LPA) production in the blood. | |||||||||||||||||||||
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References
- [1]. Chen Y, et al. Design, synthesis and anti-fibrosis evaluation of imidazo [1, 2–a] pyridine derivatives as potent ATX inhibitors[J]. Bioorganic & Medicinal Chemistry, 2021, 46: 116362.
- [2]. Joncour A, et al. Discovery, structure–activity relationship, and binding mode of an imidazo [1, 2-a] pyridine series of autotaxin inhibitors[J]. Journal of Medicinal Chemistry, 2017, 60(17): 7371-7392.
