2650253-86-2
2650253-86-2
Chemical Structure
GSK1820795A
- CAS No.: 2650253-86-2
- Formula:C35H34N8
- Molecular Weight:566.70
IUPAC Name: 3-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-5-(1-butyl-1H-benzo[d]imidazol-2-yl)-2-propyl-2H-indazole
InChIKey: XRXMDDDFTLKJHL-UHFFFAOYSA-N
SMILES: CCCN1C(CC2=CC=C(C3=C(C4=NNN=N4)C=CC=C3)C=C2)=C5C(C=CC(C6=NC(C=CC=C7)=C7N6CCCC)=C5)=N1
Biological Activity: GSK1820795A, as a telmisartan analog, is a selective hGPR132a antagonist. GSK1820795A blocks activation of yeast cells expressing hGPR132a by N-acylamides[1]. GSK1820795A is also a angiotensin II antagonists and partial PPARγ agonists (compound 38)[2].
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GSK1820795A | 99.80% | GSK1820795A, as a telmisartan analog, is a selective hGPR132a antagonist. GSK1820795A blocks activation of yeast cells expressing hGPR132a by N-acylamides. GSK1820795A is also a angiotensin II antagonists and partial PPARγ agonists (compound 38). | ||||||||||||||||||||
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GSK1820795A (Standard) | ≥98% | GSK1820795A (Standard) is the analytical standard of GSK1820795A (HY-111616). This product is intended for research and analytical applications. GSK1820795A, as a telmisartan analog, is a selective hGPR132a antagonist. GSK1820795A blocks activation of yeast cells expressing hGPR132a by N-acylamides. GSK1820795A is also a angiotensin II antagonists and partial PPARγ agonists (compound 38). | ||||||||||||||||||||
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References
- [1]. Foster JR, et al. N-Palmitoylglycine and other N-acylamides activate the lipid receptor G2A/GPR132. Pharmacol Res Perspect. 2019;7(6):e00542. [Content Brief]
- [2]. Lamotte Y, Faucher N, Sançon J, et al. Discovery of novel indazole derivatives as dual angiotensin II antagonists and partial PPARγ agonists. Bioorg Med Chem Lett. 2014;24(4):1098-1103. [Content Brief]
