2652046-41-6
Chemical Structure
Cathepsin C-IN-1
- CAS No.: 2652046-41-6
- Formula:C21H21ClF3N7
- Molecular Weight:463.89
IUPAC Name: 5-chloro-N2-(5-(4-methylpiperazin-1-yl)pyridin-2-yl)-N4-(3-(trifluoromethyl)phenyl)pyrimidine-2,4-diamine
InChIKey: JNAOGJWOQFVLOM-UHFFFAOYSA-N
SMILES: ClC1=CN=C(NC2=NC=C(N3CCN(C)CC3)C=C2)N=C1NC4=CC(C(F)(F)F)=CC=C4
Biological Activity: Cathepsin C-IN-1 is an orally active Cathepsin C inhibitor with a human IC50 of 57.4 nM. Cathepsin C-IN-1 inhibits Cat C activity and downstream neutrophil serine protease (NSP) activation. Cathepsin C-IN-1 shows anti-inflammatory activity in COPD rats, reducing pulmonary inflammation, histopathological changes, and pro-inflammatory cytokines (IFN-γ, IL-1β, IL-6, IL-17, TNF-α, GM-CSF) while increasing IL-10. Cathepsin C-IN-1 can be used for research on chronic obstructive pulmonary disease[1].
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Cathepsin C-IN-1 | Cathepsin C-IN-1 is an orally active Cathepsin C inhibitor with a human IC50 of 57.4 nM. Cathepsin C-IN-1 inhibits Cat C activity and downstream neutrophil serine protease (NSP) activation. Cathepsin C-IN-1 shows anti-inflammatory activity in COPD rats, reducing pulmonary inflammation, histopathological changes, and pro-inflammatory cytokines (IFN-γ, IL-1β, IL-6, IL-17, TNF-α, GM-CSF) while increasing IL-10. Cathepsin C-IN-1 can be used for research on chronic obstructive pulmonary disease. | |||||||||||||||||||||
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