2653225-38-6
2653225-38-6
Chemical Structure
DSM705
- CAS No.: 2653225-38-6
- Formula:C19H19F3N6O
- Molecular Weight:404.39
IUPAC Name: (R)-N-(1-(1H-1,2,4-triazol-5-yl)ethyl)-3-methyl-4-(1-(6-(trifluoromethyl)pyridin-3-yl)cyclopropyl)-1H-pyrrole-2-carboxamide
InChIKey: JUBPRXDFKLPILK-LLVKDONJSA-N
SMILES: C[C@H](C1=NC=NN1)NC(C2=C(C(C3(C4=CC=C(N=C4)C(F)(F)F)CC3)=CN2)C)=O
Biological Activity: DSM705 is a pyrrole-based Dihydroorotate Dehydrogenase (DHODH) inhibitor. DSM705 exhibits nanomolar potency against Plasmodium DHODH and Plasmodium parasites, with no inhibition of mammalian DHODHs. DSM705 is a potent antimalarial compound[1].
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DSM705 | DSM705 is a pyrrole-based Dihydroorotate Dehydrogenase (DHODH) inhibitor. DSM705 exhibits nanomolar potency against Plasmodium DHODH and Plasmodium parasites, with no inhibition of mammalian DHODHs. DSM705 is a potent antimalarial compound. | |||||||||||||||||||||
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