2660230-90-8
2660230-90-8
Chemical Structure
NLRP3-IN-25
- CAS No.: 2660230-90-8
- Formula:C17H19F3N4O5S
- Molecular Weight:448.42
InChIKey: AXBUEIBPZRUIGE-UHFFFAOYSA-N
SMILES: O=C(C1=COC(NC2=CC(C(F)(F)F)=CC=C2C)=N1)NS(=O)(N3CCOCCC3)=O
Biological Activity: NLRP3-IN-25 (compound 32) is an orally available NLRP3 inhibitor with anti-inflammatory activity. NLRP3-IN-25 attenuates renal injury in doxorubicin-induced glomerulonephritis in mice. NLRP3-IN-25 inhibits IL-1β secretion in THP-1 cells with an IC50 of 21 nM[1].
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NLRP3-IN-25 | 99.26% | NLRP3-IN-25 (compound 32) is an orally available NLRP3 inhibitor with anti-inflammatory activity. NLRP3-IN-25 attenuates renal injury in doxorubicin-induced glomerulonephritis in mice. NLRP3-IN-25 inhibits IL-1β secretion in THP-1 cells with an IC50 of 21 nM. | ||||||||||||||||||||
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