26605-69-6
Chemical Structure
Carindacillin sodium
Synonym(s): Indanyl carbenicillin sodium; CP-15464-2
- CAS No.: 26605-69-6
- Formula:C26H25N2NaO6S
- Molecular Weight:516.54
IUPAC Name: sodium (2S,5R,6R)-6-(3-((2,3-dihydro-1H-inden-5-yl)oxy)-3-oxo-2-phenylpropanamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
InChIKey: QFWPXOXWAUAYAB-XZVIDJSISA-M
SMILES: O=C(C(C1=CC=CC=C1)C(OC2=CC=C3C(CCC3)=C2)=O)N[C@H]4[C@](SC(C)5C)([H])N(C4=O)[C@H]5C(O[Na])=O
Biological Activity: Carindacillin sodium (Indanyl carbenicillin sodium; CP-15464-2) is an orally active prodrug of Carbenicillin (HY-B0525). Carindacillin sodium undergoes intestinal uptake via a proton gradient-driven carrier-mediated pathway and is rapidly hydrolyzed in vivo to release the bioactive Carbenicillin, which interferes with cell wall synthesis by inhibiting bacterial penicillin-binding proteins. Carindacillin sodium can be used in research related to bacterial infections[1][2].
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Carindacillin sodium | 98.39% | Carindacillin sodium (Indanyl carbenicillin sodium; CP-15464-2) is an orally active prodrug of Carbenicillin (HY-B0525). Carindacillin sodium undergoes intestinal uptake via a proton gradient-driven carrier-mediated pathway and is rapidly hydrolyzed in vivo to release the bioactive Carbenicillin, which interferes with cell wall synthesis by inhibiting bacterial penicillin-binding proteins. Carindacillin sodium can be used in research related to bacterial infections. | ||||||||||||||||||||
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References
- [1]. Li YH, et al. Role of the monocarboxylic acid transport system in the intestinal absorption of an orally active beta-lactam prodrug: carindacillin as a model. International journal of pharmaceutics. 1999 Nov 30;191(2):151-9.
- [2]. Michiels HG, et al. The treatment of chronic pyelonephritis with carindacillin. Current medical research and opinion. 1978;5(5):394-400.
