2662622-44-6
Chemical Structure
RET-IN-10
- CAS No.: 2662622-44-6
- Formula:C29H28N8OS
- Molecular Weight:536.65
IUPAC Name: (R)-4-(6-(4-((methyl(oxo)(phenyl)-l6-sulfanylidene)amino)piperidin-1-yl)pyridin-3-yl)-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile
InChIKey: CCWHRQDNJUAXAI-LDLOPFEMSA-N
SMILES: N#CC1=C2C(C3=CN=C(N4CCC(CC4)N=[S@](C5=CC=CC=C5)(C)=O)C=C3)=CC(C6=CN(C)N=C6)=CN2N=C1
Biological Activity: RET-IN-10 is a potent inhibitor of RET. RET loss of function mutations leads to Hirschsprung's disease, while its gain of function mutations is associated with a variety of human tumors. RET-IN-10 has the potential for the research of cancer diseases (extracted from patent WO2021135938A1, compound 18)[1].
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RET-IN-10 | RET-IN-10 is a potent inhibitor of RET. RET loss of function mutations leads to Hirschsprung's disease, while its gain of function mutations is associated with a variety of human tumors. RET-IN-10 has the potential for the research of cancer diseases (extracted from patent WO2021135938A1, compound 18). | |||||||||||||||||||||
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