2667681-85-6
Chemical Structure
IRAK4-IN-15
- CAS No.: 2667681-85-6
- Formula:C25H29FN10
- Molecular Weight:488.56
IUPAC Name: 7-fluoro-N4-isopropyl-N2-(1-(2-methyl-2-azaspiro[3.3]heptan-6-yl)-1H-pyrazol-4-yl)-6-(2-methylpyrimidin-5-yl)pyrido[3,2-d]pyrimidine-2,4-diamine
InChIKey: NYYOAOHKRVOFGH-UHFFFAOYSA-N
SMILES: CC1=NC=C(C2=NC3=C(NC(C)C)N=C(NC4=CN(C(C5)CC65CN(C)C6)N=C4)N=C3C=C2F)C=N1
Biological Activity: IRAK4-IN-15 (compound 35) is a potent and selective IRAK4 inhibitor with an IC50 of 0.002 µM. IRAK4-IN-15 shows good human PK predictions with low intrinsic clearance. IRAK4-IN-15 shows great synergistic in vitro activity against MyD88/CD79 double mutant ABC-DLBCL in combination with Acalabrutinib. [1].
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IRAK4-IN-15 | IRAK4-IN-15 (compound 35) is a potent and selective IRAK4 inhibitor with an IC50 of 0.002 µM. IRAK4-IN-15 shows good human PK predictions with low intrinsic clearance. IRAK4-IN-15 shows great synergistic in vitro activity against MyD88/CD79 double mutant ABC-DLBCL in combination with Acalabrutinib. . | |||||||||||||||||||||
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