2668-47-5
2668-47-5
Chemical Structure
5-LOX-IN-9
- CAS No.: 2668-47-5
- Formula:C20H26O
- Molecular Weight:282.43
IUPAC Name: 3,5-di-tert-butyl-[1,1'-biphenyl]-4-ol
InChIKey: JIEWQZNTUPWNMX-UHFFFAOYSA-N
SMILES: OC=1C(=CC(=CC1C(C)(C)C)C=2C=CC=CC2)C(C)(C)C
Biological Activity: 5-LOX-IN-9 is a 5-lipoxygenase and cyclooxygenase inhibitor, with an IC50 of 0.2 pM against guinea pig 5-LOX and an IC50 of 0.7 pM against bovine COX. 5-LOX-IN-9 inhibits 5-lipoxygenase via a redox-mediated mechanism. 5-LOX-IN-9 inhibits cyclooxygenase through hydrogen donor action and hydrophobicity-dependent activity[1].
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5-LOX-IN-9 | 5-LOX-IN-9 is a 5-lipoxygenase and cyclooxygenase inhibitor, with an IC50 of 0.2 pM against guinea pig 5-LOX and an IC50 of 0.7 pM against bovine COX. 5-LOX-IN-9 inhibits 5-lipoxygenase via a redox-mediated mechanism. 5-LOX-IN-9 inhibits cyclooxygenase through hydrogen donor action and hydrophobicity-dependent activity. | |||||||||||||||||||||
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