2669097-31-6
Chemical Structure
Biotin Azide Plus
- CAS No.: 2669097-31-6
- Formula:C24H42N10O5S
- Molecular Weight:582.72
IUPAC Name: N-(2-(2-(2-(2-(4-(((3-azidopropyl)amino)methyl)-1H-1,2,3-triazol-1-yl)ethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide
InChIKey: RENVLGPUZQGLEY-FUDKSRODSA-N
SMILES: [H][C@]12NC(N[C@]1(CS[C@H]2CCCCC(NCCOCCOCCOCCN3C=C(N=N3)CNCCCN=[N+]=[N-])=O)[H])=O
Biological Activity: Biotin Azide Plus is an oxazolidine reagent that integrates azide-biotin click chemistry and a photocleavable linker arm. Biotin Azide Plus not only reacts with biotin thioether to form stable sulfinimide products, but also enables bioconjugation of proteins and DNA through biotin redox-activated chemical labeling technology. Taking advantage of the streptavidin capture and photo-release properties, Biotin Azide Plus effectively facilitates the isolation of lipid-derived electrophile-protein adducts, thus finding wide application in scientific research related to fields such as SKBR3 cancer[1][2].
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Biotin Azide Plus | 98.38% | Biotin Azide Plus is an oxazolidine reagent that integrates azide-biotin click chemistry and a photocleavable linker arm. Biotin Azide Plus not only reacts with biotin thioether to form stable sulfinimide products, but also enables bioconjugation of proteins and DNA through biotin redox-activated chemical labeling technology. Taking advantage of the streptavidin capture and photo-release properties, Biotin Azide Plus effectively facilitates the isolation of lipid-derived electrophile-protein adducts, thus finding wide application in scientific research related to fields such as SKBR3 cancer. | ||||||||||||||||||||
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References
- [1]. Cotton AD, et al. Biotin as a Reactive Handle to Selectively Label Proteins and DNA with Small Molecules. ACS Chem Biol. 2022;17(12):3270-3275. [Content Brief]
- [2]. Kim H Y H, et al. An azido-biotin reagent for use in the isolation of protein adducts of lipid-derived electrophiles by streptavidin catch and photorelease[J]. Molecular & Cellular Proteomics, 2009, 8(9): 2080-2089.
