2671036-34-1
Chemical Structure
BACE1/2-IN-1
- CAS No.: 2671036-34-1
- Formula:C21H31N5OS
- Molecular Weight:401.57
IUPAC Name: (4aR,7aR)-7a-((1R,2R)-2-(2-(((1R,2R)-2-methylcyclopropyl)methoxy)propan-2-yl)cyclopropyl)-6-(pyrimidin-2-yl)-4,4a,5,6,7,7a-hexahydropyrrolo[3,4-d][1,3]thiazin-2-amine
InChIKey: BFGQEVKVRRYAQC-IFEDNLKFSA-N
SMILES: NC1=N[C@](CN(C2=NC=CC=N2)C3)([C@]4([H])C[C@]4(C(C)(C)OC[C@@H]5C[C@H]5C)[H])[C@@H]3CS1
Biological Activity: BACE1/2-IN-1 (compound 34) is a potent BACE1 and BACE2 inhibitor, with an IC50 of 0.01 and 0.0053 μM, respectively. BACE1/2-IN-1 shows a combination of lower Pgp efflux ratio and improved passive permeability. BACE1/2-IN-1 displays reduced liver microsomal metabolic stability[1].
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BACE1/2-IN-1 | BACE1/2-IN-1 (compound 34) is a potent BACE1 and BACE2 inhibitor, with an IC50 of 0.01 and 0.0053 μM, respectively. BACE1/2-IN-1 shows a combination of lower Pgp efflux ratio and improved passive permeability. BACE1/2-IN-1 displays reduced liver microsomal metabolic stability. | |||||||||||||||||||||
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