2672496-70-5
Chemical Structure
RORγt inverse agonist 14
- CAS No.: 2672496-70-5
- Formula:C26H26F8N2O6S2
- Molecular Weight:678.61
IUPAC Name: (S)-N-((6aS,7R,9aS)-9a-((4-fluorophenyl)sulfonyl)-3-(perfluoropropan-2-yl)-6,6a,7,8,9,9a-hexahydro-5H-cyclopenta[f]quinolin-7-yl)-2-hydroxy-2-methyl-3-(methylsulfonyl)propanamide
InChIKey: ABWRUZQNZVGUGR-SYMSJMEQSA-N
SMILES: O=C(N[C@@H]1CC[C@@]2(S(=O)(C3=CC=C(F)C=C3)=O)C4=C(N=C(C(C(F)(F)F)(F)C(F)(F)F)C=C4)CC[C@]21[H])[C@](C)(O)CS(=O)(C)=O
Biological Activity: RORγt inverse agonist 14 (8e) is a potent, orally active and selective RORγt inverse agonist (EC50 of 2.5 nM) with anti-inflammatory activity. RORγt inverse agonist 14 is used in the study for rheumatoid arthritis and psoriasis[1].
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RORγt inverse agonist 14 | RORγt inverse agonist 14 (8e) is a potent, orally active and selective RORγt inverse agonist (EC50 of 2.5 nM) with anti-inflammatory activity. RORγt inverse agonist 14 is used in the study for rheumatoid arthritis and psoriasis. | |||||||||||||||||||||
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