2682114-54-9
2682114-54-9
Chemical Structure
SP-96
- CAS No.: 2682114-54-9
- Formula:C25H20FN7O
- Molecular Weight:453.47
IUPAC Name: 1-(3-fluorophenyl)-3-(3-((7-(1-methyl-1H-pyrazol-4-yl)quinazolin-4-yl)amino)phenyl)urea
InChIKey: CGDYRZUPKPBLND-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=CC(NC2=C3C=CC(C4=CN(C)N=C4)=CC3=NC=N2)=C1)NC5=CC=CC(F)=C5
Biological Activity: SP-96 is a highly potent, selective and non-ATP-competitive Aurora B (IC50=0.316 nM) inhibitor and shows >2000 fold selectivity against FLT3 and KIT. SP-96 shows selective growth inhibition in NCI60 screening, incluing MDA-MD-468 (GI50=107 nM). SP-96 can be used for the research of triple negative breast cancer (TNBC)[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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SP-96 | 99.65% | SP-96 is a highly potent, selective and non-ATP-competitive Aurora B (IC50=0.316 nM) inhibitor and shows >2000 fold selectivity against FLT3 and KIT. SP-96 shows selective growth inhibition in NCI60 screening, incluing MDA-MD-468 (GI50=107 nM). SP-96 can be used for the research of triple negative breast cancer (TNBC). | ||||||||||||||||||||
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