2684270-22-0
Chemical Structure
SMALS-329
- CAS No.: 2684270-22-0
- Formula:C23H27N4O6PS
- Molecular Weight:518.52
InChIKey: ZPRFMXBJEDROHP-UHFFFAOYSA-N
SMILES: CCOP(OCC)(CS(=O)(C1=CC=C(NC(C2=C(N=CC(C(C=C3)=CC=C3C)=N2)N)=O)C=C1)=O)=O
Biological Activity: SMALS-329 is an LKB1 activator with EC50 = 8.5 μM. SMALS-329 binds to the ATP-binding pocket of STRADα and enhances the binding of the LKB1-STRAD-MO25 trimeric complex as well as the thermal stability of STRAD and LKB1. SMALS-329 enhances LKB1 kinase catalytic activity and promotes phosphorylation of downstream AMPK and SIK family substrates. SMALS-329 inhibits proliferation of multiple tumor cell lines harboring wild-type LKB1 and induces cell cycle arrest. SMALS-329 can be used for research on LKB1-related diseases, such as cancer[1].
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SMALS-329 | SMALS-329 is an LKB1 activator with EC50 = 8.5 μM. SMALS-329 binds to the ATP-binding pocket of STRADα and enhances the binding of the LKB1-STRAD-MO25 trimeric complex as well as the thermal stability of STRAD and LKB1. SMALS-329 enhances LKB1 kinase catalytic activity and promotes phosphorylation of downstream AMPK and SIK family substrates. SMALS-329 inhibits proliferation of multiple tumor cell lines harboring wild-type LKB1 and induces cell cycle arrest. SMALS-329 can be used for research on LKB1-related diseases, such as cancer. | |||||||||||||||||||||
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