2684291-60-7
Chemical Structure
Antioxidant agent-5
- CAS No.: 2684291-60-7
- Formula:C24H24N6O
- Molecular Weight:412.49
IUPAC Name: 4-((4-((5-((1H-indol-3-yl)methyl)-1,2,4-oxadiazol-3-yl)methyl)piperazin-1-yl)methyl)benzonitrile
InChIKey: LQKKHTLLMHWOGL-UHFFFAOYSA-N
SMILES: N#CC1=CC=C(C=C1)CN2CCN(CC2)CC3=NOC(CC4=CNC5=CC=CC=C45)=N3
Biological Activity: Antioxidant agent-5 (compound D-6) is a potent antioxidant agent. Antioxidant agent-5 can inhibit oxLDL (oxidized low-density lipoprotein)-induced apoptosis and the expression of ICAM-1 and VCAM-1 in VECs. Antioxidant agent-5 suppresses oxLDL-induced increase of ROS level and nuclear translocation of NF-κB. Antioxidant agent-5 protects against oxLDL-induced endothelial injury by activating Nrf2/HO-1 anti-oxidation pathway[1].
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Antioxidant agent-5 | Antioxidant agent-5 (compound D-6) is a potent antioxidant agent. Antioxidant agent-5 can inhibit oxLDL (oxidized low-density lipoprotein)-induced apoptosis and the expression of ICAM-1 and VCAM-1 in VECs. Antioxidant agent-5 suppresses oxLDL-induced increase of ROS level and nuclear translocation of NF-κB. Antioxidant agent-5 protects against oxLDL-induced endothelial injury by activating Nrf2/HO-1 anti-oxidation pathway. | |||||||||||||||||||||
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