2688119-39-1
2688119-39-1
Chemical Structure
NA-184
- CAS No.: 2688119-39-1
- Formula:C27H35ClN4O5
- Molecular Weight:531.04
InChIKey: QTTIYJOYAUFSKQ-KEKNWZKVSA-N
SMILES: ClC1=CC=CC(CNC(C(C(CC)NC([C@H](CC(C)C)NC(NCC2=CC=CC=C2)=O)=O)=O)=O)=C1OC
Biological Activity: NA-184 is a selective and brain-penetrant calpain-2 inhibitor with an IC50 of 134 nM for mouse calpain-2. NA-184 has weak inhibitory activity on calpain-1 (IC50 of 2826 nM). NA-184 does not exhibit significant inhibition on a variety of other cysteine-, serine- or metallo-proteases. NA-184 shows significant neuroprotection and can be used for the study of traumatic brain injury (TBI)[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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NA-184 | 99.66% | NA-184 is a selective and brain-penetrant calpain-2 inhibitor with an IC50 of 134 nM for mouse calpain-2. NA-184 has weak inhibitory activity on calpain-1 (IC50 of 2826 nM). NA-184 does not exhibit significant inhibition on a variety of other cysteine-, serine- or metallo-proteases. NA-184 shows significant neuroprotection and can be used for the study of traumatic brain injury (TBI). | ||||||||||||||||||||
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