2688733-96-0
Chemical Structure
ADAMTS-5-IN-3
- CAS No.: 2688733-96-0
- Formula:C20H23Cl2N3O3
- Molecular Weight:424.32
IUPAC Name: (S)-5-cyclopropyl-5-(3-((R)-7,8-dichloro-1-methyl-1,2,4,5-tetrahydro-3H-benzo[d]azepin-3-yl)-3-oxopropyl)imidazolidine-2,4-dione
InChIKey: LBFZDWQGADLLKS-YBTHPKLGSA-N
SMILES: O=C(N1C[C@@H](C2=CC(Cl)=C(Cl)C=C2CC1)C)CC[C@]3(C4CC4)C(NC(N3)=O)=O
Biological Activity: ADAMTS-5-IN-3 (Example 37-2) is a potent inhibitor of ADAMTS-5 and ADAMTS-4 with IC50s of 8 and 12 nM, respectively. ADAMTS-5-IN-3 can be used for the research of diseases involving degradation of cartilage or disruption of cartilage homeostasis, in particular osteoarthrosis and/or rheumatoid arthritis[1].
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ADAMTS-5-IN-3 | 98.89% | ADAMTS-5-IN-3 (Example 37-2) is a potent inhibitor of ADAMTS-5 and ADAMTS-4 with IC50s of 8 and 12 nM, respectively. ADAMTS-5-IN-3 can be used for the research of diseases involving degradation of cartilage or disruption of cartilage homeostasis, in particular osteoarthrosis and/or rheumatoid arthritis. | ||||||||||||||||||||
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