2688882-69-9
2688882-69-9
Chemical Structure
PROTAC SMARCA2/4 degrader-37
- CAS No.: 2688882-69-9
- Formula:C37H31ClN8O6
- Molecular Weight:719.15
InChIKey: IIYWQMYQROKRFZ-UHFFFAOYSA-N
SMILES: O=C(NC1=CC(C#CC2=CC=CC(C(NCCCCNC3=CC=CC(C(N4C5C(NC(CC5)=O)=O)=O)=C3C4=O)=O)=C2)=NC=C1)NC6=CC(Cl)=NC=C6
Biological Activity: PROTAC SMARCA2/4 degrader-37 (Example 4) is a PROTAC-based SMARCA2/4 degrader, with an IC50 of ≤0.1 μM (Pink: SMARCA2/4 lignad (HY-172446); Black: CRBN ligand (HY-41547); Linker (HY-N2407))[1].
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PROTAC SMARCA2/4 degrader-37 | PROTAC SMARCA2/4 degrader-37 (Example 4) is a PROTAC-based SMARCA2/4 degrader, with an IC50 of ≤0.1 μM (Pink: SMARCA2/4 lignad (HY-172446); Black: CRBN ligand (HY-41547); Linker (HY-N2407)). | |||||||||||||||||||||
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