2690350-15-1
Chemical Structure
d9A1-2
- CAS No.: 2690350-15-1
- Formula:C46H54FN7O9
- Molecular Weight:867.96
IUPAC Name: N-(14-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxatetradecyl)-4'-fluoro-3'-methyl-2-(4-(4-methyl-1H-imidazol-5-yl)piperidin-1-yl)-[1,1'-biphenyl]-4-carboxamide
InChIKey: WMBSSRAFHKGIRA-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C(C(N2CCC(CC2)C3=C(C)N=CN3)=C1)C4=CC(C)=C(F)C=C4)NCCOCCOCCOCCOCCNC5=CC=CC(C(N6C7C(NC(CC7)=O)=O)=O)=C5C6=O
Biological Activity: d9A1-2 is a potent SLC9A1 PROTAC degrader. d9A1-2 binds to SLC9A1 via the d9A1 warhead, recruits the CRL4CRBN E3 ubiquitin ligase through EBM, and thereby induces ubiquitination and proteasomal degradation of SLC9A1. d9A1-2 can be used for research on cancers such as acute myeloid leukemia[1].
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d9A1-2 | d9A1-2 is a potent SLC9A1 PROTAC degrader. d9A1-2 binds to SLC9A1 via the d9A1 warhead, recruits the CRL4CRBN E3 ubiquitin ligase through EBM, and thereby induces ubiquitination and proteasomal degradation of SLC9A1. d9A1-2 can be used for research on cancers such as acute myeloid leukemia. | |||||||||||||||||||||
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