2694871-86-6
Chemical Structure
BLK-IN-2
- CAS No.: 2694871-86-6
- Formula:C39H41N9O3
- Molecular Weight:683.80
IUPAC Name: (E)-N-(3-((2-((3-((1-(4-(dimethylamino)but-2-enoyl)piperidin-4-yl)amino)phenyl)amino)pyrimidin-5-yl)carbamoyl)-4-methylphenyl)isoquinoline-6-carboxamide
InChIKey: AWZWOMPLEBTAGQ-VMPITWQZSA-N
SMILES: O=C(C1=CC2=C(C=NC=C2)C=C1)NC3=CC=C(C)C(C(NC4=CN=C(NC5=CC=CC(NC6CCN(C(/C=C/CN(C)C)=O)CC6)=C5)N=C4)=O)=C3
Biological Activity: BLK-IN-2 (compound 25) is a potent and selective irreversible inhibitor of B-Lymphoid tyrosine kinase (BLK), with an IC50 of 5.9 nM. BLK-IN-2 also inhibits BTK (IC50=202.0 nM). BLK-IN-2 shows potent antiproliferative activities against several lymphoma cells[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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BLK-IN-2 | 98.61% | BLK-IN-2 (compound 25) is a potent and selective irreversible inhibitor of B-Lymphoid tyrosine kinase (BLK), with an IC50 of 5.9 nM. BLK-IN-2 also inhibits BTK (IC50=202.0 nM). BLK-IN-2 shows potent antiproliferative activities against several lymphoma cells. | ||||||||||||||||||||
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