2696407-24-4
Chemical Structure
ZA10
- CAS No.: 2696407-24-4
- Formula:C25H26N4O2
- Molecular Weight:414.50
IUPAC Name: benzofuran-2-yl(9-(2-(diethylamino)ethyl)-2-methyl-9H-benzo[d]imidazo[1,2-a]imidazol-3-yl)methanone
InChIKey: UQYHWOPWRVCWLU-UHFFFAOYSA-N
SMILES: O=C(C1=CC2=CC=CC=C2O1)C3=C(C)N=C4N(CCN(CC)CC)C5=CC=CC=C5N43
Biological Activity: ZA10 is a selective TRPM2 channel inhibitor, with an IC50 value of 8.1 μM. ZA10 can effectively suppress intracellular Ca2+ overload triggered by TRPM2 channel activation. ZA10 significantly reduce the mortality of SH-SY5Y cells induced by H2O2. ZA10 can be used for the study of ischemia-reperfusion injury, inflammation, or other neurodegenerative diseases[1].
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ZA10 | ZA10 is a selective TRPM2 channel inhibitor, with an IC50 value of 8.1 μM. ZA10 can effectively suppress intracellular Ca2+ overload triggered by TRPM2 channel activation. ZA10 significantly reduce the mortality of SH-SY5Y cells induced by H2O2. ZA10 can be used for the study of ischemia-reperfusion injury, inflammation, or other neurodegenerative diseases. | |||||||||||||||||||||
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