2699091-15-9
2699091-15-9
Chemical Structure
CDK4/6-IN-14
- CAS No.: 2699091-15-9
- Formula:C24H27ClFN7O
- Molecular Weight:483.97
IUPAC Name: 2-ethyl-6-(5-fluoro-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrimidin-4-yl)-3,4-dihydroisoquinolin-1(2H)-one hydrochloride
InChIKey: YSHOLNDNMRZMSC-UHFFFAOYSA-N
SMILES: O=C1N(CC)CCC2=C1C=CC(C3=NC(NC4=NC=C(N5CCNCC5)C=C4)=NC=C3F)=C2.Cl
Biological Activity: CDK4/6-IN-14 is a potent and highly selective CDK4 and CDK6 (CDK) inhibitor with IC50s of 10 nM and 16 nM, respectively. CDK4/6-IN-14 exhibits more than 60-fold selectivity over CDKs 1, 2, 7, and 9, and shows high selectivity among other 205 kinases[1].
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CDK4/6-IN-14 | CDK4/6-IN-14 is a potent and highly selective CDK4 and CDK6 (CDK) inhibitor with IC50s of 10 nM and 16 nM, respectively. CDK4/6-IN-14 exhibits more than 60-fold selectivity over CDKs 1, 2, 7, and 9, and shows high selectivity among other 205 kinases. | |||||||||||||||||||||
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