2699603-89-7
Chemical Structure
HPK1-IN-28
- CAS No.: 2699603-89-7
- Formula:C25H22F3N5O4
- Molecular Weight:513.47
IUPAC Name: (2-((3,5-difluoro-4-((5-(2-fluoro-4-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)phenyl)amino)-5-methyl-5,6-dihydro-4H-1,3-oxazin-5-yl)methanol
InChIKey: OLAZOTSEYGDCSN-UHFFFAOYSA-N
SMILES: FC1=C(OC2=NC=NC3=C2C(C4=C(F)C=C(OC)C=C4)=CN3)C(F)=CC(NC5=NCC(CO)(CO5)C)=C1
Biological Activity: HPK1-IN-28 is a potent inhibitor of HPK1. Hematopoietic progenitor kinase 1 (HPK1) is a negative regulator of the activation response of dendritic cells (DCs), T cells and B cells. HPK1-IN-28 enhances the body's anti-tumor immunity. HPK1-IN-28 has the potential for the research of immune-related diseases, especially tumor (extracted from patent WO2021175270A1, compound 1)[1].
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HPK1-IN-28 | HPK1-IN-28 is a potent inhibitor of HPK1. Hematopoietic progenitor kinase 1 (HPK1) is a negative regulator of the activation response of dendritic cells (DCs), T cells and B cells. HPK1-IN-28 enhances the body's anti-tumor immunity. HPK1-IN-28 has the potential for the research of immune-related diseases, especially tumor (extracted from patent WO2021175270A1, compound 1). | |||||||||||||||||||||
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