2703746-41-0
Chemical Structure
D-Ala-Lys-AMCA hydrochloride
- CAS No.: 2703746-41-0
- Formula:C21H29ClN4O6
- Molecular Weight:468.93
IUPAC Name: N2-(D-alanyl)-N6-(2-(7-amino-4-methyl-2-oxo-2H-chromen-3-yl)acetyl)-L-lysine hydrochloride
InChIKey: CUYFZQGMNMFDIC-KKJWGQAZSA-N
SMILES: NC1=CC=C(C(C)=C(CC(NCCCC[C@H](NC([C@@H](C)N)=O)C(O)=O)=O)C(O2)=O)C2=C1.[H]Cl
Biological Activity: D-Ala-Lys-AMCA hydrochloride is a known proton-coupled oligopeptide transporter 1 (PEPT1) substrate that emits blue fluorescence. D-Ala-Lys-AMCA hydrochloride may be transported into liver cancer cells and Caco-2 cells based on fluorescence analysis. D-Ala-Lys-AMCA hydrochloride can be used for characterizing PEPT1-specific substrates or inhibitors (Ex/Em = 390/480 nm)[1][2].
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D-Ala-Lys-AMCA hydrochloride | 98.13% | D-Ala-Lys-AMCA hydrochloride is a known proton-coupled oligopeptide transporter 1 (PEPT1) substrate that emits blue fluorescence. D-Ala-Lys-AMCA hydrochloride may be transported into liver cancer cells and Caco-2 cells based on fluorescence analysis. D-Ala-Lys-AMCA hydrochloride can be used for characterizing PEPT1-specific substrates or inhibitors (Ex/Em = 390/480 nm). | ||||||||||||||||||||
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References
- [1]. Gong Y, et al. Specific expression of proton-coupled oligopeptide transporter 1 in primary hepatocarcinoma-anovel strategy for tumor-targeted therapy. Oncol Lett. 2017 Oct;14(4):4158-4166. [Content Brief]
- [2]. Groneberg DA, et al. Intestinal peptide transport: ex vivo uptake studies and localization of peptide carrier PEPT1. Am J Physiol Gastrointest Liver Physiol. 2001 Sep;281(3):G697-704. [Content Brief]
