2705900-81-6
Chemical Structure
ALK5-IN-8
- CAS No.: 2705900-81-6
- Formula:C19H15FN4O2
- Molecular Weight:350.35
IUPAC Name: ethyl 5-(3-(4-fluorophenyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carboxylate
InChIKey: GFFVSPZTWRNCIU-UHFFFAOYSA-N
SMILES: O=C(C1=C2C=C(C3=CNN=C3C4=CC=C(F)C=C4)C=CN2N=C1)OCC
Biological Activity: ALK5-IN-8 is a potent inhibitor of TGFβRI (ALK5). ALK5-IN-8 Inhibits the phosphorylation of ALK5 on its downstream signaling proteins (Smad2 or Smad3) by blocking the binding of TGFβRI to ligands, thereby affecting or blocking TGF-β signaling. ALK5-IN-8 has the potential for the research of various ALK5-mediated related diseases (extracted from patent WO2021190425A1, compound 1)[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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ALK5-IN-8 | 98.21% | ALK5-IN-8 is a potent inhibitor of TGFβRI (ALK5). ALK5-IN-8 Inhibits the phosphorylation of ALK5 on its downstream signaling proteins (Smad2 or Smad3) by blocking the binding of TGFβRI to ligands, thereby affecting or blocking TGF-β signaling. ALK5-IN-8 has the potential for the research of various ALK5-mediated related diseases (extracted from patent WO2021190425A1, compound 1). | ||||||||||||||||||||
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