27067-70-5
Chemical Structure
5-Hydroxynoracronycine
- CAS No.: 27067-70-5
- Formula:C19H17NO4
- Molecular Weight:323.34
InChIKey: JZQDCDLYNFZBIG-UHFFFAOYSA-N
SMILES: O=C1C2=C(N(C)C3=C4C=CC(C)(C)OC4=CC(O)=C13)C(O)=CC=C2
Biological Activity: 5-Hydroxynoracronycine is a selective inhibitor targeting Leishmania, HIV-1 protease, and nitric oxide (NO) production. 5-Hydroxynoracronycine has an IC50 of 93.1 μmol/L against HIV-1 protease and an IC50 of 0.19 mg/mL for scavenging DPPH free radicals. 5-Hydroxynoracronycine exerts anti-leishmanial, anti-HIV, antioxidant and antibacterial activities by inhibiting pathogen proliferation, enzyme activity and inflammation-related NO excessive production. 5-Hydroxynoracronycine can be used in the research of leishmaniasis, HIV infection, and inflammation-related diseases[1][2].
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5-Hydroxynoracronycine | 5-Hydroxynoracronycine is a selective inhibitor targeting Leishmania, HIV-1 protease, and nitric oxide (NO) production. 5-Hydroxynoracronycine has an IC50 of 93.1 μmol/L against HIV-1 protease and an IC50 of 0.19 mg/mL for scavenging DPPH free radicals. 5-Hydroxynoracronycine exerts anti-leishmanial, anti-HIV, antioxidant and antibacterial activities by inhibiting pathogen proliferation, enzyme activity and inflammation-related NO excessive production. 5-Hydroxynoracronycine can be used in the research of leishmaniasis, HIV infection, and inflammation-related diseases. | |||||||||||||||||||||
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References
- [1]. Panthong K, et al. Benzene, coumarin and quinolinone derivatives from roots of Citrus hystrix. Phytochemistry. 2013 Apr;88:79-84. [Content Brief]
- [2]. Astelbauer F, et al. Anti-leishmanial activity of plant-derived acridones, flavaglines, and sulfur-containing amides. Vector Borne Zoonotic Dis. 2011 Jul;11(7):793-8. [Content Brief]
