2711105-54-1
2711105-54-1
Chemical Structure
EGFR-IN-36
- CAS No.: 2711105-54-1
- Formula:C26H25ClN6O2
- Molecular Weight:488.97
IUPAC Name: 1-(3-(4-amino-5-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl)piperidin-1-yl)prop-2-en-1-one
InChIKey: QZSUQMZPWHXHOE-UHFFFAOYSA-N
SMILES: C=CC(N1CC(C2=CC(C3=CC=C(OCC4=NC=CC=C4)C(Cl)=C3)=C5C(N)=NC=NN52)CCC1)=O
Biological Activity: EGFR-IN-36 is a potent EGFR inhibitor with IC50s of 19.09 nM, 120.01 nM, 2.35 nM for EGFR (WT), HER2 (WT), HER2 (A775_G776insYVMA), respectively. EGFR-IN-36 has potential for wild and/or mutant EGFR and/or HER2 kinase mediated tumors research[1].
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EGFR-IN-36 | EGFR-IN-36 is a potent EGFR inhibitor with IC50s of 19.09 nM, 120.01 nM, 2.35 nM for EGFR (WT), HER2 (WT), HER2 (A775_G776insYVMA), respectively. EGFR-IN-36 has potential for wild and/or mutant EGFR and/or HER2 kinase mediated tumors research. | |||||||||||||||||||||
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