2714414-11-4
2714414-11-4
Chemical Structure
Practolol-d7
- CAS No.: 2714414-11-4
- Formula:C14H15D7N2O3
- Molecular Weight:273.38
IUPAC Name: N-(4-(2-hydroxy-3-((propan-2-yl-d7)amino)propoxy)phenyl)acetamide
InChIKey: DURULFYMVIFBIR-SVMCCORHSA-N
SMILES: CC(NC1=CC=C(OCC(O)CNC([2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])C=C1)=O
Biological Activity: Practolol-d7 is the deuterium labeled Practolol. Practolol is a potent and selective β1-adrenergic receptor antagonist. Practolol can be used for the research of cardiac arrhythmias[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Practolol-d7 | Practolol-d7 is the deuterium labeled Practolol. Practolol is a potent and selective β1-adrenergic receptor antagonist. Practolol can be used for the research of cardiac arrhythmias. | |||||||||||||||||||||
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Practolol (Standard) | ≥98% | Practolol (Standard) is the analytical standard of Practolol. This product is intended for research and analytical applications. Practolol is a potent and selective β1-adrenergic receptor antagonist. Practolol can be used for the research of cardiac arrhythmias. | ||||||||||||||||||||
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Practolol | 99.80% | Practolol is a potent and selective β1-adrenergic receptor antagonist. Practolol can be used for the research of cardiac arrhythmias. | ||||||||||||||||||||
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Prenalterol | 99.18% | Prenalterol is an orally active selective β1-adrenergic receptor agonist with positive inotropic effects. Prenalterol can be used in research on cardiovascular diseases such as chronic heart failure. | ||||||||||||||||||||
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Prenalterol hydrochloride | Prenalterol hydrochloride is an orally active selective β1-adrenergic receptor agonist with positive inotropic effects. Prenalterol hydrochloride can be used in research on cardiovascular diseases such as chronic heart failure. | |||||||||||||||||||||
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Metoprolol acid (Standard) | ≥98% | Metoprolol acid (Standard) is the analytical standard of Metoprolol acid. This product is intended for research and analytical applications. Metoprolol acid (Atenolol acid) is a urinary metabolite with no pharmacological activity. Metoprolol acid does not exert its pharmacological effects in vivo. Metoprolol acid can be detected by solid phase extraction and reversed phase high performance liquid chromatography. The analysis of metoprolol acid requires specific conditions, such as the use of fluorescence detection and specific eluents. | ||||||||||||||||||||
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Atenolol | 99.94% | Atenolol ((RS)-Atenolol) is a cardioselective β1-adrenergic receptor blocker, with a Ki of 697 nM at β1-adrenoceptor in guine pig left ventricle membrane. Atenolol can be used for the research of hypertension and angina pectoris. | ||||||||||||||||||||
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(S)-Atenolol | 95.0% | (S)-Atenolol is a potent beta-adrenoreceptor blocker. (S)-Atenolol has the potential for the research of cardiovascular disorder. | ||||||||||||||||||||
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Atenolol hydrochloride | Atenolol hydrochloride is a cardioselective β1-adrenergic receptor blocker, with a Ki of 697 nM at β1-adrenoceptor in guine pig left ventricle membrane. Atenolol hydrochloride can be used for the research of hypertension and angina pectoris. | |||||||||||||||||||||
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(R)-(+)-Atenolol | 98.57% | (R)-(+)-Atenolol is the less active enantiomer of the (R,S)-atenolol. (R,S)-atenolol is a β-adrenergic receptor antagonist. | ||||||||||||||||||||
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Metoprolol impurity 2 | Metoprolol impurity 2 is an impurity of Metoprolol. | |||||||||||||||||||||
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Acebutolol impurity 4 | Acebutolol impurity 4 is an impurity of Acebutolol. | |||||||||||||||||||||
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Metoprolol impurity 8 | Metoprolol impurity 8 is an impurity of Metoprolol. | |||||||||||||||||||||
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References
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
- [2]. Iakovidis D, et, al. In vitro activity of RO363, a beta1-adrenoceptor selective agonist. Br J Pharmacol. 1980 Apr;68(4):677-85. [Content Brief]
- [3]. Adashi EY, et, al. Stimulation of beta 2-adrenergic responsiveness by follicle-stimulating hormone in rat granulosa cells in vitro and in vivo. Endocrinology. 1981 Jun;108(6):2170-8. [Content Brief]
