271576-80-8
271576-80-8
Chemical Structure
SD 0006
Synonym(s): SD-06
- CAS No.: 271576-80-8
- Formula:C20H20ClN5O2
- Molecular Weight:397.86
IUPAC Name: 1-(4-(5-(4-chlorophenyl)-4-(pyrimidin-4-yl)-1H-pyrazol-3-yl)piperidin-1-yl)-2-hydroxyethan-1-one
InChIKey: CATQHDWESBRRQA-UHFFFAOYSA-N
SMILES: OCC(N1CCC(CC1)C2=NNC(C3=CC=C(C=C3)Cl)=C2C4=NC=NC=C4)=O
Biological Activity: SD 0006 (SD-06) is an orally active, selective, ATP-competitive and potent diaryl pyrazole inhibitor of p38α MAP kinase, with an IC50 of 110 nM for p38α[1][2].
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SD 0006 | 98.22% | SD 0006 (SD-06) is an orally active, selective, ATP-competitive and potent diaryl pyrazole inhibitor of p38α MAP kinase, with an IC50 of 110 nM for p38α. | ||||||||||||||||||||
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SD 0006 (Standard) | ≥98% | SD 0006 (Standard) is the analytical standard of SD 0006 (HY-11087). This product is intended for research and analytical applications. SD 0006 (SD-06) is an orally active, selective, ATP-competitive and potent diaryl pyrazole inhibitor of p38α MAP Kinase, with an IC50 of 110 nM for p38α. | ||||||||||||||||||||
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References
- [1]. Burnette BL, et al. SD0006: a potent, selective and orally available inhibitor of p38 kinase. Pharmacology. 2009;84(1):42-60. [Content Brief]
- [2]. Walker JK, et al. Identification of SD-0006, a potent diaryl pyrazole inhibitor of p38 MAP kinase. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2634-8. [Content Brief]
