271579-12-5
271579-12-5
Chemical Structure
Thonningianin B
- CAS No.: 271579-12-5
- Formula:C35H30O17
- Molecular Weight:722.60
IUPAC Name: (11aR,13S,14R,15R,15aS)-13-(3,5-dihydroxy-4-(3-phenylpropanoyl)phenoxy)-2,3,4,5,6,7,14,15-octahydroxy-11,11a,13,14,15,15a-hexahydrodibenzo[g,i]pyrano[3,2-b][1,5]dioxacycloundecine-9,17-dione
InChIKey: UJNCWORGHSATHA-XWSAIMBSSA-N
SMILES: O=C(C1=C(O)C=C(O[C@H]2[C@@H]([C@H]([C@@H]([C@@H](COC3=O)O2)OC(C4=CC(O)=C(O)C(O)=C4C5=C(O)C(O)=C(O)C=C53)=O)O)O)C=C1O)CCC6=CC=CC=C6
Biological Activity: Thonningianin B is an antioxidant and an autophagy enhancer[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Thonningianin B | 99.68% | Thonningianin B is an antioxidant and an autophagy enhancer. | ||||||||||||||||||||
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Strictinin | 97.15% | Strictinin is an orally active phenolic compound. Strictinin reduces xanthine oxidase activity, uric acid production, and the activation of ERK1/2, JNK, NF-κB, and NLRP3 inflammasome components in hepatocytes treated with Xanthine (HY-W017389). Strictinin decreases elevated serum uric acid levels and enhanced xanthine oxidase activity in mice treated with potassium oxonate. Strictinin acts as a ROR1 inhibitor and exhibits anticancer activity against highly aggressive non-androgen-dependent prostate cancer. Strictinin induces cancer cell apoptosis (apoptosis), arrests cell cycle, and inhibits cancer cell migration, invasion, and epithelial-mesenchymal transition. Strictinin modulates gut microbiota, inhibits bacterial growth and biofilm formation, accelerates small intestinal transit, and blocks viral entry and replication. Strictinin can be used in research related to hyperuricemia, androgen receptor-negative non-androgen-dependent prostate cancer, triple-negative breast cancer, bacterial infections, constipation, coronavirus infections, dental caries, and infections caused by influenza A, influenza B, and human parainfluenza virus type 1. | ||||||||||||||||||||
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Pinocembrin-7-O-(4'',6''-hexahydroxydiphenoyl)-β-D-glucoside | Pinocembrin-7-O-(4'',6''-hexahydroxydiphenoyl)-β-D-glucoside is an α-Amylase (HY-B2193) inhibitor with an IC50 of 0.14 μmol/mL. Pinocembrin-7-O-(4'',6''-hexahydroxydiphenoyl)-β-D-glucoside can be used for the research of diabetes mellitus. | |||||||||||||||||||||
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Gemin D | Gemin D is a polyphenolic compound extracted from eucalyptus leaves. Gemin D has cellular antioxidant activity (EC50 = 15.57 μM). Gemin D can be used for research on inflammatory conditions. | |||||||||||||||||||||
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Pinocembrin 7-O-[4′′,6′′-(S)-HHDP]-β-D-glucoside | Pinocembrin 7-O-[4′′,6′′-(S)-HHDP]-β-D-glucoside (compound 3) is a polyphenol that has weak antiproliferative activity in PDGF-induced HSC-T6 cells (IC50: 200 μM). | |||||||||||||||||||||
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4-Hydroxythonningianin B | 4-Hydroxythonningianin B (4'-O-(4,6-O-Hexahydroxydiphenoyl-β-D-glucopyranosyl)phloretin) is a natural chalcone. | |||||||||||||||||||||
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4',6'-O-(S)-Hexahydroxydiphenylsalicin | 4',6'-O-(S)-Hexahydroxydiphenylsalicin is a phenolic glucoside that can be isolated from the stem bark of Alangium plantanifolium. | |||||||||||||||||||||
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Alangitanifoliside A | Alangitanifoliside A (Compound 1) is a phenolic glucoside isolated from the stem bark of Alangium plantanifolium. | |||||||||||||||||||||
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Thonningianin A | 99.73% | Thonningianin A, an ellagitannin, is isolated from the methanolic extract of the African medicinal herb, Thonningia sanguinea. The antioxidant properties of Th A involve radical scavenging, anti-superoxide formation and metal chelation. Anti-cancer activities. | ||||||||||||||||||||
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Pinocembrin 7-O-[3''-O-galloyl-4'',6''-hexahydroxydiphenoyl]-β-D-glucoside | 98.77% | Pinocembrin 7-O-[3''-O-galloyl-4'',6''-hexahydroxydiphenoyl]-β-D-glucoside is a TRPV1 antagonist and HDAC7 inhibitor. Pinocembrin 7-O-[3''-O-galloyl-4'',6''-hexahydroxydiphenoyl]-β-D-glucoside blocks TRPV1-mediated calcium influx, suppresses phosphorylation of p65, IκBα, p38, JNK, and ERK1/2, inhibiting NF-κB and MAPK signaling cascades. Pinocembrin 7-O-[3''-O-galloyl-4'',6''-hexahydroxydiphenoyl]-β-D-glucoside reduces production and gene expression of pro-inflammatory cytokines IL-1β, IL-6, and TNF-α. Pinocembrin 7-O-[3''-O-galloyl-4'',6''-hexahydroxydiphenoyl]-β-D-glucoside exhibits potent analgesic activity, elevates thermal pain threshold and mechanical pain threshold in murine models. Pinocembrin 7-O-[3''-O-galloyl-4'',6''-hexahydroxydiphenoyl]-β-D-glucoside restores CD8+ T cell infiltration into bladder cancer tumors and improves bladder cancer immunotherapy efficacy. Pinocembrin 7-O-[3''-O-galloyl-4'',6''-hexahydroxydiphenoyl]-β-D-glucoside can be used for the researches of painand bladder cancer. | ||||||||||||||||||||
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2,6-Dihydroxyacetophenone-4-O-[4,6-(S)-hexahydroxydiphenoyl]-β-D-glucose | 2,6-Dihydroxyacetophenone-4-O-[4,6-(S)-hexahydroxydiphenoyl]-β-D-glucose is a novel polyphenol/ellagitannin-type glucoside. 2,6-Dihydroxyacetophenone-4-O-[4,6-(S)-hexahydroxydiphenoyl]-β-D-glucose mediates antiproliferative effects via platelet-derived growth factor (PDGF)-induced hepatic stellate cells. 2,6-Dihydroxyacetophenone-4-O-[4,6-(S)-hexahydroxydiphenoyl]-β-D-glucose can be used for the research of hepatic fibrosis. | |||||||||||||||||||||
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References
- [1]. Ohtani II, et al. Thonningianins A and B, new antioxidants from the African medicinal herb Thonningia sanguinea. J Nat Prod. 2000 May;63(5):676-9. [Content Brief]
- [2]. Zhou XG, et al. Targeting microglial autophagic degradation of the NLRP3 inflammasome for identification of thonningianin A in Alzheimer's disease. Inflamm Regen. 2022 Aug 3;42(1):25. [Content Brief]
