2719736-43-1
Chemical Structure
DNA-PK-IN-5
- CAS No.: 2719736-43-1
- Formula:C21H22N8O2
- Molecular Weight:418.45
IUPAC Name: 9-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-7-methyl-2-((7-methylquinoxalin-6-yl)amino)-7,9-dihydro-8H-purin-8-one
InChIKey: BIXRNGNRPTYYQW-UHFFFAOYSA-N
SMILES: O=C1N(N2CC3OC(CC3)C2)C4=NC(NC5=C(C)C=C6N=CC=NC6=C5)=NC=C4N1C
Biological Activity: DNA-PK-IN-5 is a potent inhibitor of DNA-PK. DNA-PK-IN-5 inhibits DNA-PKcs activity, thus greatly reducing tumor DNA repair and inducing cells to enter the apoptotic program. DNA-PK-IN-5 enhances the sensitivity of tumor tissues to radiotherapy, overcomes the problem of agent resistance, and enhances the inhibitory effect on a variety of solid tumors and hematological tumors (extracted from patent WO2021204111A1, compound 2)[1].
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DNA-PK-IN-5 | DNA-PK-IN-5 is a potent inhibitor of DNA-PK. DNA-PK-IN-5 inhibits DNA-PKcs activity, thus greatly reducing tumor DNA repair and inducing cells to enter the apoptotic program. DNA-PK-IN-5 enhances the sensitivity of tumor tissues to radiotherapy, overcomes the problem of agent resistance, and enhances the inhibitory effect on a variety of solid tumors and hematological tumors (extracted from patent WO2021204111A1, compound 2). | |||||||||||||||||||||
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