2724247-62-3
Chemical Structure
Antimalarial agent 66
- CAS No.: 2724247-62-3
- Formula:C27H20F4N4O3
- Molecular Weight:524.48
IUPAC Name: (3S,4S)-N-(3-cyano-4-fluorophenyl)-3-(6-cyclopropoxypyridin-3-yl)-1-oxo-2-(2,2,2-trifluoroethyl)-1,2,3,4-tetrahydroisoquinoline-4-carboxamide
InChIKey: KYICPNWURYGJCB-BJKOFHAPSA-N
SMILES: C(NC1=CC(C#N)=C(F)C=C1)(=O)[C@@H]2[C@H](N(CC(F)(F)F)C(=O)C=3C2=CC=CC3)C=4C=CC(OC5CC5)=NC4
Biological Activity: Antimalarial agent 66 is an orally effective Na+ATPase (PfATP-4) inhibitor and antimalarial agent with an EC50 of 19 nM against the P. falciparum 3D7 strain. Antimalarial agent 66 kills malaria parasites by inhibiting PfATP-4, leading to elevated intracellular sodium ion concentration. Antimalarial agent 66 can be used for malaria research[1].
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Antimalarial agent 66 | Antimalarial agent 66 is an orally effective Na+ATPase (PfATP-4) inhibitor and antimalarial agent with an EC50 of 19 nM against the P. falciparum 3D7 strain. Antimalarial agent 66 kills malaria parasites by inhibiting PfATP-4, leading to elevated intracellular sodium ion concentration. Antimalarial agent 66 can be used for malaria research. | |||||||||||||||||||||
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