2724919-69-9
Chemical Structure
KB05yne
- CAS No.: 2724919-69-9
- Formula:C22H21BrN2O2
- Molecular Weight:425.32
InChIKey: OVRPBGDKSIRDNY-UHFFFAOYSA-N
SMILES: O=C(NCCCCC#C)C1=CC=C(N(C2=CC=C(Br)C=C2)C(C=C)=O)C=C1
Biological Activity: KB05yne is a site-selective, alkyne-functionalized electrophilic "probe" fragment probe designed for covalent ligand discovery, with preferential reactivity toward specific cysteine residues in proteins. KB05yne strongly labels wild-type target proteins (e.g., CDKN2AIP, HPCAL1) but does not label their cysteine-to-alanine mutants, confirming site-specific cysteine reactivity. KB05yne can be used for the discovery and optimization of site-specific covalent ligands, and is applicable to proteins with diverse structures and functions, especially in studies targeting cysteine residues in cancer-related or difficult-to-purify proteins[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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KB05yne | 99.97% | KB05yne is a site-selective, alkyne-functionalized electrophilic "probe" fragment probe designed for covalent ligand discovery, with preferential reactivity toward specific cysteine residues in proteins. KB05yne strongly labels wild-type target proteins (e.g., CDKN2AIP, HPCAL1) but does not label their cysteine-to-alanine mutants, confirming site-specific cysteine reactivity. KB05yne can be used for the discovery and optimization of site-specific covalent ligands, and is applicable to proteins with diverse structures and functions, especially in studies targeting cysteine residues in cancer-related or difficult-to-purify proteins. | ||||||||||||||||||||
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