272769-49-0
272769-49-0
Chemical Structure
A-620223
- CAS No.: 272769-49-0
- Formula:C16H22N4O
- Molecular Weight:286.37
IUPAC Name: 2-(1-propylpiperidin-4-yl)-1H-benzo[d]imidazole-4-carboxamide
InChIKey: KXSIHXHEHABEJX-UHFFFAOYSA-N
SMILES: CCCN(CC1)CCC1C2=NC3=C(C(N)=O)C=CC=C3N2
Biological Activity: A-620223 is a PARP-1 inhibitor with a Ki of 8 nM against PARP-1 and EC50 of 3 nM in a whole cell assay. A-620223 demonstrates good in vivo efficacy in a B16F10 subcutaneous murine melanoma model in combination with Temozolomide (TMZ) (HY-17364) and in an MX-1 breast xenograph model in combination with Cisplatin (HY-17394). A-620223 can be used for the studies of melanoma and breast cancer[1].
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A-620223 | A-620223 is a PARP-1 inhibitor with a Ki of 8 nM against PARP-1 and EC50 of 3 nM in a whole cell assay. A-620223 demonstrates good in vivo efficacy in a B16F10 subcutaneous murine melanoma model in combination with Temozolomide (TMZ) (HY-17364) and in an MX-1 breast xenograph model in combination with Cisplatin (HY-17394). A-620223 can be used for the studies of melanoma and breast cancer. | |||||||||||||||||||||
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