2728655-31-8
2728655-31-8
Chemical Structure
Veligrotug
Synonym(s): AVE1642; VRDN-001
- CAS No.: 2728655-31-8
- Formula:N/A
- Molecular Weight:(147.7 kDa)
SMILES: [Veligrotug]
Biological Activity: Veligrotug (AVE1642) is a selective, fully human IGF-1R antagonist antibody with a Kd value of 0.55 nM for hIGF-1R. Veligrotug blocks the phosphorylation of downstream AKT. Veligrotug is applicable to research related to thyroid eye disease[1][2].
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Veligrotug | 99.25% | Veligrotug (AVE1642) is a selective, fully human IGF-1R antagonist antibody with a Kd value of 0.55 nM for hIGF-1R. Veligrotug blocks the phosphorylation of downstream AKT. Veligrotug is applicable to research related to thyroid eye disease. | ||||||||||||||||||||
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References
- [1]. Turbin R, et al. Veligrotug (VRDN-001), a Full Antagonist Monoclonal Antibody to IGF-1 Receptor, in Active Thyroid Eye Disease (TED): THRIVE Phase 3 Efficacy and Safety Topline Results[J]. Investigative Ophthalmology & Visual Science, 2025, 66(8): 4302-4302.
- [2]. Kaplan R, et al. Preclinical pharmacology, pharmacokinetics, and pharmacodynamics of veligrotug, a full antagonist antibody to the IGF-1 receptor in development for thyroid eye disease. MAbs. 2025;17(1):2585616. [Content Brief]
