2728727-91-9
Chemical Structure
GSK137
- CAS No.: 2728727-91-9
- Formula:C21H19FN6
- Molecular Weight:374.41
IUPAC Name: 5-((5S,7R)-3-fluoro-7-(2-methylpyridin-3-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-5-yl)quinolin-2-amine
InChIKey: WSRZNMRSHUJOED-RBUKOAKNSA-N
SMILES: FC1=C(N2N=C1)N[C@@H](C[C@@H]2C3=C(N=CC=C3)C)C4=CC=CC5=C4C=CC(N)=N5
Biological Activity: GSK137 is an orally active BCL6 inhibitor. GSK137 competitively blocks the protein-protein interactions of BCL6 with the corepressors SMRT, NCOR1, and BCOR. GSK137 produces only weak cell cycle arrest in multiple BCL6-positive diffuse large B-cell lymphoma cell lines and has almost no effect on tumor cell viability. GSK137 inhibits the generation of mouse germinal center B cells and Tfh cells, and downregulates TNP-specific IgM and IgG antibody levels. GSK137 can be used for research related to diffuse large B-cell lymphoma[1].
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GSK137 | GSK137 is an orally active BCL6 inhibitor. GSK137 competitively blocks the protein-protein interactions of BCL6 with the corepressors SMRT, NCOR1, and BCOR. GSK137 produces only weak cell cycle arrest in multiple BCL6-positive diffuse large B-cell lymphoma cell lines and has almost no effect on tumor cell viability. GSK137 inhibits the generation of mouse germinal center B cells and Tfh cells, and downregulates TNP-specific IgM and IgG antibody levels. GSK137 can be used for research related to diffuse large B-cell lymphoma. | |||||||||||||||||||||
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