2732-18-5
2732-18-5
Chemical Structure
5,7-Dihydroxycoumarin
- CAS No.: 2732-18-5
- Formula:C9H6O4
- Molecular Weight:178.14
IUPAC Name: 5,7-dihydroxy-2H-chromen-2-one
InChIKey: KIQQFVJHWNCGAU-UHFFFAOYSA-N
SMILES: O=C1C=CC2=C(C=C(C=C2O)O)O1
Biological Activity: 5,7-Dihydroxycoumarin is a coumarin isolated from the inflorescences of Macaranga triloba. 5,7-dihydroxycoumarin displays antibacterial characteristics with an MIC value in the range of 1000 mg/mL to >1000 mg/mL. Some 5,7-dihydroxycoumarin derivatives have antioxidant properties[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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5,7-Dihydroxycoumarin | 99.47% | 5,7-Dihydroxycoumarin is a coumarin isolated from the inflorescences of Macaranga triloba. 5,7-dihydroxycoumarin displays antibacterial characteristics with an MIC value in the range of 1000 mg/mL to >1000 mg/mL. Some 5,7-dihydroxycoumarin derivatives have antioxidant properties. | ||||||||||||||||||||
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5,7-Dihydroxycoumarin (Standard) | ≥98% | 5,7-Dihydroxycoumarin (Standard) is the analytical standard of 5,7-Dihydroxycoumarin (HY-W072009). This product is intended for research and analytical applications. 5,7-Dihydroxycoumarin is a coumarin isolated from the inflorescences of Macaranga triloba. 5,7-dihydroxycoumarin displays antibacterial characteristics with an MIC value in the range of 1000 mg/mL to >1000 mg/mL. Some 5,7-dihydroxycoumarin derivatives have antioxidant properties. | ||||||||||||||||||||
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4-Hydroxy-6-methylcoumarin | 95.0% | 4-Hydroxy-6-methylcoumarin is a Coumarin product. | ||||||||||||||||||||
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4-Methylumbelliferone (Standard) | 99.24% | 4-Methylumbelliferone (Standard) is the analytical standard of 4-Methylumbelliferone. This product is intended for research and analytical applications. 4-Methylumbelliferone is a hyaluronic acid biosynthesis inhibitor with antitumoral and antimetastatic effects. | ||||||||||||||||||||
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4-Methylumbelliferone-13C4 | 4-Methylumbelliferone-13C4 (Hymecromone-13C4) is the 13C-labeled 4-Methylumbelliferone (HY-N0187). 4-Methylumbelliferone is a hyaluronic acid biosynthesis inhibitor with antitumoral and antimetastatic effects. | |||||||||||||||||||||
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Esculetin (Standard) | 99.91% | Esculetin (Standard) is the analytical standard of Esculetin. This product is intended for research and analytical applications. Esculetin is an active ingredient extracted mainly from the bark of Fraxinus rhynchophylla. Esculetin inhibits platelet-derived growth factor (PDGF)-induced airway smooth muscle cells (ASMCs) phenotype switching through inhibition of PI3K/Akt pathway. Esculetin has antioxidant, antiinflammatory, and antitumor activities. | ||||||||||||||||||||
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5-Hydroxy-7-methoxycoumarin | 5-Hydroxy-7-methoxycoumarin is a coumarin compound present in the whole plant of Euphorbia kansuensis, with an IC50 > 40 μM against five human cancer cell lines. | |||||||||||||||||||||
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5,7-Dihydroxychromone (Standard) | ≥98% | 5,7-Dihydroxychromone (Standard) is the analytical standard of 5,7-Dihydroxychromone (HY-N1970). This product is intended for research and analytical applications. 5,7-Dihydroxychromone is a flavonoid compound with antioxidant properties. 5,7-Dihydroxychromone induces Nrf2 nuclear translocation, increases Nrf2/ARE binding activity, and up-regulates Nrf2-dependent antioxidant genes HO-1, NQO1, GCLc. 5,7-Dihydroxychromone attenuates excessive ROS generation, inhibits activated caspase-3, caspase-9, cleaved PARP expression, and prevents neuronal apoptosis and cell death. 5,7-Dihydroxychromone increases LXRα and PPARγ mRNA expression, induces preadipocyte differentiation, and regulates blood glucose levels. 5,7-Dihydroxychromone inhibits radial growth of soil pathogenic fungi, radicle elongation of select seedlings, and transiently inhibits Bradyrhizobium sp. growth in high mannitol medium. 5,7-Dihydroxychromone can be used for the research of Parkinson’s disease, type 2 diabetes mellitus and pathogenic fungal infection. | ||||||||||||||||||||
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6-Hydroxy-4-methylcoumarin | 99.30% | 6-Hydroxy-4-methylcoumarin (compound 9) is a coumarins secondary metabolites and has anticancer activity. | ||||||||||||||||||||
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4-Hydroxycoumarin | 99.96% | 4-Hydroxycoumarin is an orally active coumarin derivative, one of the most versatile heterocyclic scaffolds, often used in the synthesis of various organic compounds. 4-Hydroxycoumarin possesses both electrophilic and nucleophilic properties. 4-Hydroxycoumarin is an HIV protease inhibitor and tyrosine kinase inhibitor. 4-Hydroxycoumarin has anti-inflammatory, antibacterial and anti-tumor effects. | ||||||||||||||||||||
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7-Hydroxy-5-methoxycoumarin | 7-Hydroxy-5-methoxycoumarin is a phloroglucinol-type furocoumarins, a potent naturally-occurring insect antifeedant. | |||||||||||||||||||||
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4,7-Dihydroxycoumarin | 98.25% | 4,7-Dihydroxycoumarin is an EGFR inhibitor, estrogen receptor inhibitor, and progesterone receptor inhibitor. 4,7-Dihydroxycoumarin against breast cancer cells with an IC50 velue of 18.36 μg/mL. 4,7-Dihydroxycoumarin can be used for the research of breast cancer. | ||||||||||||||||||||
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References
- [1]. Ishak Zakaria, et al. Flavonoids with antiplasmodial and cytotoxic activities of Macaranga triloba. Fitoterapia. 2012 Jul;83(5):968-72. [Content Brief]
- [2]. Yi-Ping Chin, et al. Synthesis and evaluation of antibacterial activities of 5,7-dihydroxycoumarin derivatives. Arch Pharm (Weinheim). 2011 Jun;344(6):386-93. [Content Brief]
- [3]. Lin M H, et al. Antioxidant properties of 5, 7-dihydroxycoumarin derivatives in in vitro cell-free and cell-containing systems. Journal of Experimental & Clinical Medicine, 2011, 3(3): 126-131.
