2733597-15-2
2733597-15-2
Chemical Structure
N1-Acetylspermidine-d6 hydrochloride
- CAS No.: 2733597-15-2
- Formula:C9H17D6Cl2N3O
- Molecular Weight:266.24
IUPAC Name: N-(2,6-dimethylphenyl)-2-((propan-2-yl-d7)amino)acetamide hydrochloride
InChIKey: IVLOLMVLUOGVCZ-MSYAZHJTSA-N
SMILES: CC(NC([2H])([2H])C([2H])([2H])C([2H])([2H])NCCCCN)=O.Cl.Cl
Biological Activity: N1-Acetylspermidine-d6 (hydrochloride) is the deuterium labeled N1-Acetylspermidine hydrochloride. N1-Acetylspermidine hydrochloride is an acetyl derivative of polyamine. N1-acetylspermine is the substrate for the polyamine oxidase (PAO). N1-Acetylspermidine hydrochloride selectively elevates its level in human colorectal adenocarcinomas. N1-acetylspermidine shows cleavage efficiency at apurinic sites in DNA[1][2][3].
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N1-Acetylspermidine-d6 hydrochloride | 96.87% | N1-Acetylspermidine-d6 (hydrochloride) is the deuterium labeled N1-Acetylspermidine hydrochloride. N1-Acetylspermidine hydrochloride is an acetyl derivative of polyamine. N1-acetylspermine is the substrate for the polyamine oxidase (PAO). N1-Acetylspermidine hydrochloride selectively elevates its level in human colorectal adenocarcinomas. N1-acetylspermidine shows cleavage efficiency at apurinic sites in DNA. | ||||||||||||||||||||
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N1-Acetylspermidine hydrochloride (Standard) | ≥98% | N1-Acetylspermidine (hydrochloride) (Standard) is the analytical standard of N1-Acetylspermidine (hydrochloride). This product is intended for research and analytical applications. N1-Acetylspermidine hydrochloride is an acetyl derivative of polyamines and a substrate for polyamine oxidase (PAO). N1-Acetylspermidine hydrochloride can promote Apoptosis in combination with Procyanidins. N1-Acetylspermidine hydrochloride has a certain cleavage efficiency at apurinic sites of DNA. N1-Acetylspermidine hydrochloride can be used in colorectal cancer research. | ||||||||||||||||||||
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N1-Acetylspermidine-d3 hydrochloride | N1-Acetylspermidine-d3 hydrochloride is the deuterium labeled N1-Acetylspermidine hydrochloride (HY-113056A). N1-Acetylspermidine hydrochloride is an acetyl derivative of polyamines and a substrate for polyamine oxidase (PAO). N1-Acetylspermidine hydrochloride can promote Apoptosis in combination with Procyanidins. N1-Acetylspermidine hydrochloride has a certain cleavage efficiency at apurinic sites of DNA. N1-Acetylspermidine hydrochloride can be used in colorectal cancer research. | |||||||||||||||||||||
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N1-Acetylspermidine hydrochloride | 99.88% | N1-Acetylspermidine hydrochloride is an acetyl derivative of polyamines and a substrate for polyamine oxidase (PAO). N1-Acetylspermidine hydrochloride can promote Apoptosis in combination with Procyanidins. N1-Acetylspermidine hydrochloride has a certain cleavage efficiency at apurinic sites of DNA. N1-Acetylspermidine hydrochloride can be used in colorectal cancer research. | ||||||||||||||||||||
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Monoacetylcadaverine hydrochloride | 98.0% | Monoacetylcadaverine hydrochloride is a metabolite of the endogenous polyamine cadaverine. | ||||||||||||||||||||
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N-(5-Aminopentyl)acetamide (Standard) | 99.92% | N-(5-Aminopentyl)acetamide (Standard) is the analytical standard of N-(5-Aminopentyl)acetamide. This product is intended for research and analytical applications. N-(5-Aminopentyl)acetamide is the acetylated form of the polyamine cadaverine. | ||||||||||||||||||||
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N-Acetylputrescine hydrochloride (Standard) | ≥98% | N-Acetylputrescine hydrochloride (Standard) is the analytical standard for N-Acetylputrescine hydrochloride (HY-113100). This product is intended for research and analytical applications. N-Acetylputrescine hydrochloride is a polyamine metabolite that regulates cell proliferation and signal transduction mainly by participating in polyamine acetylation modification. N-Acetylputrescine hydrochloride may reduce the positive charge of polyamines, affect protein-nucleic acid interactions, and promote cell growth. The concentration changes of N-Acetylputrescine hydrochloride can help disease diagnosis (such as early screening and efficacy evaluation of lung cancer) and microbial cell wall structure research. N-Acetylputrescine hydrochloride can be used as a potential biomarker for the progression of squamous cell carcinoma of the lung (SCCL) and Parkinson's disease (PD). | ||||||||||||||||||||
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Putreanine dihydrochloride | 99.60% | Putreanine dihydrochloride is an alkaline diamino monocarboxylic acid amino acid that exists exclusively in the central nervous system of mammals and birds. Putreanine dihydrochloride reaches its highest concentration in the caudal region of the brain. Putreanine dihydrochloride appears in the brain tissue of rats 2 weeks after birth, and its concentration gradually increases to adult levels over several months. | ||||||||||||||||||||
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N8-Acetylspermidine dihydrochloride | 98.0% | N8-Acetylspermidine dihydrochloride is a polyamine metabolite. N8-Acetylspermidine dihydrochloride can be oxidatively deaminated by copper amine oxidase. N8-Acetylspermidine dihydrochloride can also induce the differentiation of PC12 cells and promote neurite outgrowth. | ||||||||||||||||||||
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N8-Acetylspermidine dihydrochloride (Standard) | ≥98% | N8-Acetylspermidine dihydrochloride (Standard) is the analytical standard of N8-Acetylspermidine dihydrochloride. This product is intended for research and analytical applications. N8-Acetylspermidine dihydrochloride is a polyamine metabolite. N8-Acetylspermidine dihydrochloride can be oxidatively deaminated by copper amine oxidase. N8-Acetylspermidine dihydrochloride can also induce the differentiation of PC12 cells and promote neurite outgrowth. | ||||||||||||||||||||
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C4-Amide-C4-NH2 | C4-Amide-C4-NH2 is an active compound. C4-Amide-C4-NH2 can be used in a variety of biochemical studies. | |||||||||||||||||||||
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6-Aminocaproic acid-d6 | 99.93% | 6-Aminocaproic acid-d6 is deuterium labeled 6-Aminocaproic acid. 6-Aminocaproic acid (EACA), a monoamino carboxylic acid, is a potent and orally active inhibitor of plasmin and plasminogen. 6-Aminocaproic acid is a potent antifibrinolytic agent. 6-Aminocaproic acid prevents clot lysis through the competitive binding of lysine residues on plasminogen, inhibiting plasmin formation and reducing fibrinolysis. 6-Aminocaproic acid can be used for the research of bleeding disorders. | ||||||||||||||||||||
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Spermidine hydrochloride | 98.0% | Spermidine hydrochloride maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine hydrochloride significantly decreases the H2O2 and O2.- contents. | ||||||||||||||||||||
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Spermidine-d8 hydrochloride | 95% | Spermidine-d8 (hydrochloride)e is the deuterium labeled Spermidine trihydrochloride. Spermidine hydrochloride maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine hydrochloride significantly decreases the H2O2 and O2.- contents. | ||||||||||||||||||||
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Spermidine-13C4 hydrochloride | 99.80% | Spermidine-13C4 (hydrochloride) is the 13C-labeled Spermidine trihydrochloride. Spermidine hydrochloride maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine hydrochloride significantly decreases the H2O2 and O2.- contents. | ||||||||||||||||||||
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Spermidine-d6 | 96.07% | Spermidine-d6 is the deuterium labeled Spermidine. Spermidine maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine significantly decreases the H2O2 and O2.- contents. | ||||||||||||||||||||
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L-Citrulline-d6 | L-Citrulline-d6 is the deuterium labeled L-Citrulline. L-Citrulline is an amino acid derived from ornithine in the catabolism of proline or glutamine and glutamate, or from l-arginine via arginine-citrulline pathway. | |||||||||||||||||||||
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N1,N1'-(Propane-1,3-diyl)bis(propane-1,3-diamine)-d12 | N1,N1'-(Propane-1,3-diyl)bis(propane-1,3-diamine)-d12 is the deuterium labeled N1,N1'-(Propane-1,3-diyl)bis(propane-1,3-diamine). | |||||||||||||||||||||
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N-Acetylputrescine (Standard) | 99.47% | N-Acetylputrescine (Standard) (NAP (Standard)) is the analytical standard of N-Acetylputrescine (HY-W342604). This product is intended for research and analytical applications. N-Acetylputrescine is a polyamine metabolite that regulates cell proliferation and signal transduction mainly by participating in polyamine acetylation modification. N-Acetylputrescine may reduce the positive charge of polyamines, affect protein-nucleic acid interactions, and promote cell growth. The concentration changes of N-Acetylputrescine can help disease diagnosis (such as early screening and efficacy evaluation of lung cancer) and microbial cell wall structure research. N-Acetylputrescine can be used as a potential biomarker for the progression of squamous cell carcinoma of the lung (SCCL) and Parkinson's disease (PD). | ||||||||||||||||||||
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N1-Acetyl triethylenetetramine | N1-Acetyl triethylenetetramine is a polyamine derivative with a free amino terminus. N1-Acetyl triethylenetetramine serves as a substrate for spermidine/spermine N1-acetyltransferase (SSAT) and exerts competitive inhibitory effects on APAO and SMO. N1-Acetyl triethylenetetramine can be catalyzed to undergo acetylation by recombinant mouse SSAT. It is applicable in metabolism-related research. | |||||||||||||||||||||
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N1-Acetyl triethylenetetramine-d4 | N1-Acetyl triethylenetetramine-d4 is deuterated N1-Acetyl triethylenetetramine and can be used as an internal standard in plasma extracts. | |||||||||||||||||||||
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N1-Acetylspermidine-d6 | N1-Acetylspermidine-d6 (N-[3-(Acetylamino)propyl]-1,4-butanediamine-d6) is the deuterium labeled N1-Acetylspermidine (HY-113056). | |||||||||||||||||||||
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N,N'-Dimethyl-3,3'-dithiodipropionamide-d6 | N,N'-Dimethyl-3,3'-dithiodipropionamide-d6 (Propanamide, 3,3'-dithiobis[n-methyl-d6) is the deuterium labeled N,N'-Dimethyl-3,3'-Dithiodipropionamide (HY-W045680). | |||||||||||||||||||||
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References
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
- [2]. Royo M, et al. Mechanistic studies of mouse polyamine oxidase with N1,N12-bisethylspermine as a substrate. Biochemistry. 2005 May 10;44(18):7079-84. [Content Brief]
- [3]. Haukanes BI, et al. Action of spermidine, N1-acetylspermidine, and N8-acetylspermidine at apurinic sites in DNA. [Content Brief]
