2734060-73-0
2734060-73-0
Chemical Structure
KRAS G12C inhibitor 25
- CAS No.: 2734060-73-0
- Formula:C32H41N7O2
- Molecular Weight:555.71
IUPAC Name: 2-((S)-1-acryloyl-4-((R)-7-(3,4-dihydroquinolin-1(2H)-yl)-2-(((S)-1-methylpyrrolidin-2-yl)methoxy)-5,6,7,8-tetrahydroquinazolin-4-yl)piperazin-2-yl)acetonitrile
InChIKey: BVNQVRSIVGNVET-ZNZIZOMTSA-N
SMILES: CN(CCC1)[C@@H]1COC2=NC(N3C[C@@H](N(CC3)C(C=C)=O)CC#N)=C4C(C[C@@](N5C6=CC=CC=C6CCC5)([H])CC4)=N2
Biological Activity: KRAS G12C inhibitor 25 is a KRAS G12C inhibitor. KRAS G12C inhibitor 25 inhibits SOSl-assisted GDP/GTP exchanging activity of KRAS-G12C mutant (IC50=0.48 nM). From WO2021216770A1 compound 3[1].
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KRAS G12C inhibitor 25 | KRAS G12C inhibitor 25 is a KRAS G12C inhibitor. KRAS G12C inhibitor 25 inhibits SOSl-assisted GDP/GTP exchanging activity of KRAS-G12C mutant (IC50=0.48 nM). From WO2021216770A1 compound 3. | |||||||||||||||||||||
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