2734858-38-7
Chemical Structure
CAP GAU m7G(5')ppp(5')(2'OMeA)pU
- CAS No.: 2734858-38-7
- Formula:C31H42N12O25P4
- Molecular Weight:1106.63
InChIKey: FTIHNRSFQMJZNB-MAXJDXETSA-N
SMILES: O[C@H]1[C@@H](O)[C@H](N2C(NC(N)=NC3=O)=C3[N+](C)=C2)O[C@@H]1COP(OP(OP(OC[C@@H]4O[C@H](N5C6=NC=NC(N)=C6N=C5)[C@@H](OC)[C@H]4OP(OC[C@@H]7[C@@H](O)[C@@H](O)[C@H](N8C(NC(C=C8)=O)=O)O7)(O)=O)(O)=O)(O)=O)([O-])=O
Biological Activity: CAP GAU m7G (5') ppp (5')(2'OMeA) pU is a trinucleotide cap analog with a Cap1 structure. CAP GAU m7G (5') ppp (5')(2'OMeA) pU can be co-transcriptionally incorporated into the 5' end of mRNA during T7 RNA polymerase-mediated in vitro transcription to form a natural Cap1 cap structure. CAP GAU m7G (5') ppp (5')(2'OMeA) pU enhances mRNA translation efficiency and reduces innate immune recognition, and it has been used in the preparation of self-amplifying mRNA rabies vaccines. CAP GAU m7G (5') ppp (5')(2'OMeA) pU can be applied to research related to in vitro mRNA transcription and mRNA vaccines[1].
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CAP GAU m7G(5')ppp(5')(2'OMeA)pU | CAP GAU m7G (5') ppp (5')(2'OMeA) pU is a trinucleotide cap analog with a Cap1 structure. CAP GAU m7G (5') ppp (5')(2'OMeA) pU can be co-transcriptionally incorporated into the 5' end of mRNA during T7 RNA polymerase-mediated in vitro transcription to form a natural Cap1 cap structure. CAP GAU m7G (5') ppp (5')(2'OMeA) pU enhances mRNA translation efficiency and reduces innate immune recognition, and it has been used in the preparation of self-amplifying mRNA rabies vaccines. CAP GAU m7G (5') ppp (5')(2'OMeA) pU can be applied to research related to in vitro mRNA transcription and mRNA vaccines. | |||||||||||||||||||||
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