2734918-75-1
2734918-75-1
Chemical Structure
Tyk2-IN-23
- CAS No.: 2734918-75-1
- Formula:C26H27ClFN5O2
- Molecular Weight:495.98
InChIKey: YOPXFEDKMCSNEE-UHFFFAOYSA-N
SMILES: O=C1NCCC21CCN(C3=C(C)C=NC(NC4=CC=C(OCC5=CC=CC(F)=C5)C(Cl)=C4)=N3)CC2
Biological Activity: Tyk2-IN-23 is a potent, orally active, selective TYK2 inhibitor (IC50 = 18 nM), exhibiting more than > 70-fold selectivity over JAK1/2/3 isoforms. Tyk2-IN-23 potently inhibits p-STAT3 in TYK2-dependent signaling activated by IFN-α and IL-10. Tyk2-IN-23 potently inhibits IFN-α-induced STAT1 phosphorylation in H9 cells. Tyk2-IN-23 can be used for the study of alopecia areata and allergic Rhinitis[1].
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Tyk2-IN-23 | Tyk2-IN-23 is a potent, orally active, selective TYK2 inhibitor (IC50 = 18 nM), exhibiting more than > 70-fold selectivity over JAK1/2/3 isoforms. Tyk2-IN-23 potently inhibits p-STAT3 in TYK2-dependent signaling activated by IFN-α and IL-10. Tyk2-IN-23 potently inhibits IFN-α-induced STAT1 phosphorylation in H9 cells. Tyk2-IN-23 can be used for the study of alopecia areata and allergic Rhinitis. | |||||||||||||||||||||
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