2734922-78-0
2734922-78-0
Chemical Structure
NVP-DFF332
Synonym(s): HIF-2α-IN-8
- CAS No.: 2734922-78-0
- Formula:C17H11ClF7N3O
- Molecular Weight:441.73
IUPAC Name: (S)-1'-chloro-8-(difluoromethoxy)-8',8'-difluoro-6-(trifluoromethyl)-7',8'-dihydro-3H,6'H-spiro[imidazo[1,2-a]pyridine-2,5'-isoquinoline]
InChIKey: OARXSQSRBRVMQA-OAHLLOKOSA-N
SMILES: FC1(C2=C(Cl)N=CC=C2[C@]3(CC1)N=C4N(C=C(C=C4OC(F)F)C(F)(F)F)C3)F
Biological Activity: HIF-2α-IN-8 is a potent and orally active HIF2α inhibitor with IC50 values of 9, 37, 246 nM for HIF2α SPA, HIF2α iScript, HIF2α HRE RGA, respectively. HIF-2α-IN-8 shows antitumor activity[1].
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NVP-DFF332 | 99.31% | HIF-2α-IN-8 is a potent and orally active HIF2α inhibitor with IC50 values of 9, 37, 246 nM for HIF2α SPA, HIF2α iScript, HIF2α HRE RGA, respectively. HIF-2α-IN-8 shows antitumor activity. | ||||||||||||||||||||
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