2737283-20-2
2737283-20-2
Chemical Structure
EGFR ligand-2
- CAS No.: 2737283-20-2
- Formula:C30H35N9O
- Molecular Weight:537.66
IUPAC Name: (S)-1-(3-(2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-8-(phenylamino)-9H-purin-9-yl)piperidin-1-yl)prop-2-en-1-one
InChIKey: WPMXUVGZCGGVSI-VWLOTQADSA-N
SMILES: C=CC(N1CCC[C@@H](C1)N2C(NC3=CC=CC=C3)=NC4=CN=C(N=C42)NC5=CC=C(C=C5)N6CCN(CC6)C)=O
Biological Activity: EGFR ligand-2 (compound C4), a covalent EGFR ligand, is a EGFR mutant inhibitor with IC50s of 21 nM and 48 nM for EGFRL858R and EGFRL858R/T790M, respectively. EGFR ligand-2 can be used to synthesize PROTAC[1].
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EGFR ligand-2 | EGFR ligand-2 (compound C4), a covalent EGFR ligand, is a EGFR mutant inhibitor with IC50s of 21 nM and 48 nM for EGFRL858R and EGFRL858R/T790M, respectively. EGFR ligand-2 can be used to synthesize PROTAC. | |||||||||||||||||||||
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