2740536-09-6
2740536-09-6
Chemical Structure
14-3-3σ/ERRγ stabilizer-1
- CAS No.: 2740536-09-6
- Formula:C14H22N2OS2
- Molecular Weight:298.47
InChIKey: PGDJLFFVTFIDSH-UHFFFAOYSA-N
SMILES: CN(CCSSCCN(C(C1=CC=CC=C1)=O)C)C
Biological Activity: 14-3-3σ/ERRγ stabilizer-1 (compound 4) is a molecular glue and a 14-3-3σ/ERRγ protein-protein interaction stabilizer. 14-3-3σ/ERRγ stabilizer-1 binds to the 14-3-3σ binding groove and tethers via disulfide bond formation with C180 of the ERRγ pS179 phosphopeptide, thereby stabilizing the 14-3-3σ/ERRγ protein complex[1].
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14-3-3σ/ERRγ stabilizer-1 | 14-3-3σ/ERRγ stabilizer-1 (compound 4) is a molecular glue and a 14-3-3σ/ERRγ protein-protein interaction stabilizer. 14-3-3σ/ERRγ stabilizer-1 binds to the 14-3-3σ binding groove and tethers via disulfide bond formation with C180 of the ERRγ pS179 phosphopeptide, thereby stabilizing the 14-3-3σ/ERRγ protein complex. | |||||||||||||||||||||
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