2743448-32-8
2743448-32-8
Chemical Structure
Dim16
- CAS No.: 2743448-32-8
- Formula:C29H38IN5
- Molecular Weight:583.55
InChIKey: PYVKCKXGZHKWHI-UHFFFAOYSA-N
SMILES: CC(C)(C)CCCN1C(C2=CN=C(N2CCCCCNC)I)=NC=C1C3=CC=C4C=CC=CC4=C3
Biological Activity: Dim16 is a dual PCSK9 inhibitor and HMG-CoAR inhibitor, with an IC50 of 0.8 nM against human PCSK9 and an IC50 of 146.8 μM against HMG-CoAR. Dim16 disrupts the PCSK9-LDLR protein-protein interaction, inhibits the catalytic activity of HMG-CoAR, enhances cellular uptake of extracellular LDL, and suppresses PCSK9-induced platelet aggregation. Dim16 can be used in research related to hypercholesterolemia[1].
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Dim16 | Dim16 is a dual PCSK9 inhibitor and HMG-CoAR inhibitor, with an IC50 of 0.8 nM against human PCSK9 and an IC50 of 146.8 μM against HMG-CoAR. Dim16 disrupts the PCSK9-LDLR protein-protein interaction, inhibits the catalytic activity of HMG-CoAR, enhances cellular uptake of extracellular LDL, and suppresses PCSK9-induced platelet aggregation. Dim16 can be used in research related to hypercholesterolemia. | |||||||||||||||||||||
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