2747100-02-1
Chemical Structure
PI3K-IN-28
- CAS No.: 2747100-02-1
- Formula:C26H16F9N3O3S2
- Molecular Weight:653.54
IUPAC Name: 4-((E)-(((Z)-3,4-diphenylthiazol-2(3H)-ylidene)hydrazono)methyl)phenyl 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonate
InChIKey: HNBHTMGDVLPSOT-HSTUYHSTSA-N
SMILES: O=S(OC1=CC=C(C=C1)/C=N/N=C2SC=C(N\2C3=CC=CC=C3)C4=CC=CC=C4)(C(F)(C(F)(C(F)(C(F)(F)F)F)F)F)=O
Biological Activity: PI3K-IN-28 (Compound 6c) is a potent inhibitor of PI3K. PI3K-IN-28 displays the most potent activity with lower toxic effects on MCF-10a. PI3K-IN-28 displays half-maximal inhibitory concentration (IC50, μM) values of 5.8, 2.3, and 7.9. PI3K-IN-28 is the most potent one with a selectivity index (SI) of 39 and is considered as a latent lead for further optimization of anticancer agents[1].
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PI3K-IN-28 | PI3K-IN-28 (Compound 6c) is a potent inhibitor of PI3K. PI3K-IN-28 displays the most potent activity with lower toxic effects on MCF-10a. PI3K-IN-28 displays half-maximal inhibitory concentration (IC50, μM) values of 5.8, 2.3, and 7.9. PI3K-IN-28 is the most potent one with a selectivity index (SI) of 39 and is considered as a latent lead for further optimization of anticancer agents. | |||||||||||||||||||||
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