2747919-19-1
Chemical Structure
CDK7/9-IN-1
- CAS No.: 2747919-19-1
- Formula:C24H32F3N5O2
- Molecular Weight:479.54
IUPAC Name: (R)-1-(2-((4-((3-isopropyl-6-(trifluoromethyl)imidazo[1,2-a]pyridin-8-yl)amino)piperidin-1-yl)methyl)morpholino)prop-2-en-1-one
InChIKey: NLPHXSGNLCQYEN-LJQANCHMSA-N
SMILES: CC(C1=CN=C2N1C=C(C(F)(F)F)C=C2NC3CCN(CC3)C[C@@H]4CN(CCO4)C(C=C)=O)C
Biological Activity: CDK7/9-IN-1 is a cyclin-dependent kinases 7/9 (CDK7/9) inhibitor. CDK7/9-IN-1 selectively inhibits CDK7 over CDK9. CDK7/9-IN-1 inhibits CDK7 with IC50s of 0.0656 μM and 0.00574 μM without pre-incubation and after 3 hours pre-incubation, respectively. CDK7/9-IN-1 inhibits CDK9 with an IC50 of 2.14 μM after 3 hours pre-incubation. CDK7/9-IN-1 can be used for the research of cancer[1].
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CDK7/9-IN-1 | CDK7/9-IN-1 is a cyclin-dependent kinases 7/9 (CDK7/9) inhibitor. CDK7/9-IN-1 selectively inhibits CDK7 over CDK9. CDK7/9-IN-1 inhibits CDK7 with IC50s of 0.0656 μM and 0.00574 μM without pre-incubation and after 3 hours pre-incubation, respectively. CDK7/9-IN-1 inhibits CDK9 with an IC50 of 2.14 μM after 3 hours pre-incubation. CDK7/9-IN-1 can be used for the research of cancer. | |||||||||||||||||||||
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