2748162-29-8
2748162-29-8
Chemical Structure
JBJ-02-112-05
- CAS No.: 2748162-29-8
- Formula:C27H20N4O2S
- Molecular Weight:464.54
IUPAC Name: 2-(6-(1H-indol-5-yl)-1-oxoisoindolin-2-yl)-2-phenyl-N-(thiazol-2-yl)acetamide
InChIKey: GRSCCESMUDSCTN-UHFFFAOYSA-N
SMILES: O=C(NC1=NC=CS1)C(N2C(C(C=C(C3=CC(C=CN4)=C4C=C3)C=C5)=C5C2)=O)C6=CC=CC=C6
Biological Activity: JBJ-02-112-05 is a potent, mutant-selective, allosteric and orally active EGFR inhibitor with an IC50 of 15 nM for EGFRL858R/T790M[1].
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JBJ-02-112-05 | JBJ-02-112-05 is a potent, mutant-selective, allosteric and orally active EGFR inhibitor with an IC50 of 15 nM for EGFRL858R/T790M. | |||||||||||||||||||||
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