2748337-86-0
2748337-86-0
Chemical Structure
AZ12601011
- CAS No.: 2748337-86-0
- Formula:C19H15N5
- Molecular Weight:313.36
IUPAC Name: 2-(pyridin-2-yl)-4-(1H-pyrrolo[3,2-c]pyridin-1-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine
InChIKey: KQCNNLRNSIXEJU-UHFFFAOYSA-N
SMILES: C1(C2=NC=CC=C2)=NC(N3C=CC4=C3C=CN=C4)=C(CCC5)C5=N1
Biological Activity: AZ12601011 is an orally active, selective TGFBR1 kinase inhibitor with an IC50 of 18 nM and a Kd of 2.9 nM. AZ12601011 inhibits phosphorylation of SMAD2 via selectively inhibiting ALK4, TGFBR1, and ALK7. AZ12601011 inhibits mammary tumor growth [1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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AZ12601011 | 99.78% | AZ12601011 is an orally active, selective TGFBR1 kinase inhibitor with an IC50 of 18 nM and a Kd of 2.9 nM. AZ12601011 inhibits phosphorylation of SMAD2 via selectively inhibiting ALK4, TGFBR1, and ALK7. AZ12601011 inhibits mammary tumor growth . | ||||||||||||||||||||
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