2750644-44-9
2750644-44-9
Chemical Structure
Glue02-35
- CAS No.: 2750644-44-9
- Formula:C15H12F3N7OS
- Molecular Weight:395.36
InChIKey: OHXPBNOCQXTJOV-UHFFFAOYSA-N
SMILES: O=C(NC1=NC=C(C(F)(F)F)S1)C2CN(C3=NC=NC(N4C=CC=N4)=C3)C2
Biological Activity: Glue02-35 is a CCNK molecular glue degrader with a DC50 < 0.1 μM. Glue02-35 binds to the kinase domain of CDK12, promotes the formation of a ternary complex between CDK12 and the DDB1-CUL4-RBX1 E3 ubiquitin ligase complex, and converts CDK12 into a substrate-specific receptor, inducing polyubiquitination and proteasomal degradation of CCNK. Glue02-35 inhibits cancer cell proliferation. Glue02-35 can be used for cancer-related research[1].
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Glue02-35 | Glue02-35 is a CCNK molecular glue degrader with a DC50 < 0.1 μM. Glue02-35 binds to the kinase domain of CDK12, promotes the formation of a ternary complex between CDK12 and the DDB1-CUL4-RBX1 E3 ubiquitin ligase complex, and converts CDK12 into a substrate-specific receptor, inducing polyubiquitination and proteasomal degradation of CCNK. Glue02-35 inhibits cancer cell proliferation. Glue02-35 can be used for cancer-related research. | |||||||||||||||||||||
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